NRgize+ by SynternalsHigh quality NAD, Quercetin, B vitamin and antioxidant complex for whole body wellness, fatigue and healthy ageing.Home > NRgize+ NAD Healthy Ageing Supplement by SynternalsOrder your supplements by phone or email!Are you bringing out the best in your skin? Book a 20 minute complimentary skin assessment or video consultation to learn more about the right products for your skin! We believe that looking your best begins with feeling your best on the inside – and any skincare regime must be complimented by optimal nutrition. NRgize+ by SynternalsContains: Nicotinamide riboside (NR), Niacinamide (aka nicotinamide), Resveratrol, and QuercetinWhy we love it: this powerful combination from Synternals contains vitamins that have been scientifically proven to aid longevity, strong immunity, skin ageing and cellular health.How it works: Nicotinamide riboside (NR) is a bioavailable form of vitamin B3, elevating cellular NAD+ levels in mature adults and supporting cellular energy and repair. Niacinamide (aka nicotinamide) is the only NAD+ booster that crosses the blood brain barrier. This helps to maintains and support skin health and hydration, while reducing inflammation. Human studies highlighted the reduction of non-malignant skin cancer incidence. Resveratrol is a potent antioxidant combating oxidative stress, promoting cellular health. Quercetin is a powerful flavonoid found in plants, enhancing cellular maintenance, repair, and longevity while preserving NAD+ levels via inhibiting the CD38 enzyme that depletes NAD+. It also has well documented anti-inflammatory properties, as a potent antioxidant combating oxidative stress, promoting cellular health.Shop Enquire with us to purchaseANRgize+ Key Benefits EElevates cellular NAD+ levels in mature adults EMaintains and supports skin health and hydration ESupports cellular energy and repair EMaintains and supports nervous system health EAssists in carbohydrate, fat and protein breakdown ESupports gut health and nutrient absorption EReduces free radical damage in the bodyAWho is NRgize+ Suitable For?We are now facing more cellular challenges thanever before, due to negative environmental impacts increased stress levels, poor soil quality and questionable ingredients present in our food. We know that as part of the natural ageing process, our NAD+ levels decline. NRgize+ is recommended for all those whose dietary intake might be inadequate and they are concerned with: EAge-related health decline EBoosting vital NAD+ levels as they mature EImproving cellular and total body energy levels EOptimising cellular metabolism EReducing the impact of free radical damage to their cells ESupplementing with bioavailable forms of B3 without facial flushing ESupporting a healthy digestive system ESupporting healthy skinADietary information: ENo added dairy, gluten, shellfish, soy or yeastDose: follow instructions on label or take as directed by your healthcare practitionerAWarnings:Vitamins don’t replace a balanced diet. Always read the label and use as directed. Do not exceed the recommended dose. If you are pregnant or considering becoming pregnant, talk to your doctor before commencing use. Why is Cellular Health Important For How We Age – Both Aesthetically and Internally?Cellular health is the foundation of whole-body health.The optimal functioning of our organs and systems relies on the health of individual cells. Each cell plays a crucial role inprocesses such as gene expression, molecular synthesis, waste disposal, and defence against pathogens. Every cellmust generate energy to facilitate these processes, and this is carried out within the mitochondria, often referred to as the‘cellular powerhouse’.What are Mitochondria?Mitochondria are specialised organelles, responsible for generating adenosine triphosphate (ATP), the primary energy currency of the cell. ATP provides a power source for all our cellular functions. Mitochondria are crucial for life and all processes our cells need to function and survive. Optimal mitochondrial function is therefore essential for an optimised healthspan.Key Functions of Mitochondria Include:Energy Production: Mitochondria are responsible for breaking down glucose from carbohydrates and fatty acidsRegulation of Cellular Metabolism: Mitochondria play a crucial role in regulating the metabolic activity of the cell, and through the energy produced, promoting cell multiplication, growth, and other vital processes.Cellular Signalling: Mitochondria are emerging as possessing functions beyond ATP production. It is involved in signalling processes through mitochondrial reactive oxygen species, calcium signalling, and immune signalling, contributing to various cellular functions and responses.Apoptosis: Mitochondria play a key role in apoptosis or programmed cell death, a vital process for maintaining cellular health and eliminating damaged or unnecessary cells that can accumulate and impair tissue function.By supporting mitochondrial health, individuals can enhance their overall well-being and vitality. The process of energy production by the mitochondria requires nicotinamide adenine dinucleotide (NAD+) to be in constant supply.So Why is NAD+ a Buzz Word In Longevity and Ageing Science?The mitochondria create molecules called ATP (adenosine triphosphate) and this process can only occur when nicotinamide adenine dinucleotide (NAD+) is available to the mitochondria.Therefore, optimal health begins at the fundamental level of maintaining optimal NAD+ levels for cellular wellbeing, highlighting the critical role of the mitochondria in maintaining cellular function, overall healthspan and vitality.What is NAD+ (nicotinamide adenine dinucleotide)?NAD+ is a coenzyme found in every living cell in our body and is essential for maintaining cellular health and energy.NAD+ serves as a key cofactor for enzymes involved in energy production and DNA repair, making it vital for cellular function and longevity. NAD+ is an electron shuttle service and participates in redox reactions by accepting and donating electrons. In its oxidised form it exists as NAD+, the form that takes up electrons and in its reduced form, it exists as NADH which donates its electrons to molecules in the body. This electron exchange is essential for life giving chemical processes and reactions occurring in the cells. Key Functions of NAD+ include:• Energy Production: NAD+ acts as a major player in cellular energy metabolism, carrying electrons in reactions that power ATP (cellular energy) production in the mitochondria.• Cellular Health and Resilience: NAD+ is involved in the cellular stress response, helping cells resist damage from factors like toxins and ageing.• DNA Repair: NAD+ is involved in regulation of PARPs (poly ADP-ribose polymerases) that repair DNA damage, safeguarding the integrity of our genetic code.• Sirtuin Activity: NAD+ serves as a substrate and fuel source for sirtuins. Sirtuins are proteins linked to healthy ageing, metabolism regulation, cellular survival, and longevity.How is NAD+ made?NAD+ is primarily produced through the salvage pathway, recycling existing NAD+ precursors such as niacinamide (NAM) and nicotinamide riboside (NR) instead of creating it from scratch. NR and NAM can then be converted to NMN (nicotinamide mononucleotide) under the influence of the enzyme nicotinamide phosphoribosyl transferase (NAMPT).The enzyme nicotinamide mononucleotide adenylyl transferase (NMNAT aka NMN transferase) then steps in and converts this NMN to NAD+.The body prioritises recycling existing NAD+ precursors from NR and niacinamide (NAM) via the salvage pathway as this is more energy efficient for the cells than making NAD+ from scratch. The salvage pathway also has the advantage of using the NAMPT enzyme to adjust NAD+ levels for the cells, based on the needs of the cell.NAD+ levels naturally decline with age and are associated with the hallmarks of ageing:This decline in NAD+ levels can lead to decreased cellular function and increased susceptibility to age-related diseases such as neurodegenerative, metabolic, and cardiovascular disease – as well as chronic inflammation.Studies show that boosting NAD+ levels can support cellular repair mechanisms, enhance energy metabolism, promote overall well-being, and increase longevity. The primary methods of increasing NAD+ blood levels include:• Exercise• Fasting or caloric restriction• Healthy nutrition• Supplementing with NAD+ precursors or boosters such as nicotinamide riboside (NR), niacinamide (NAM), resveratrol and quercetinNRgize+ is a dietary supplement formulated to support the body’s energy levels and vitality. At the core of this formula are nicotinamide riboside and niacinamide, two forms of vitamin B3 which support NAD+ levels in the body, particularly in mature adults. The formulation also contains the antioxidants quercetin and resveratrol, which assist in the management of free radical levels in the body.
